Resistance Mechanisms in GIST Overcoming Secondary Mutations 2026

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2025-12-17 07:09:41 - Traduire -

The Genetic Complexity of Treatment Evasion The development of Resistance Mechanisms in GIST is the primary cause of treatment failure and disease progression in patients receiving tyrosine kinase inhibitors. The cancer cells, initially sensitive to the drugs, evolve under selective pressure by acquiring new genetic alterations, most often secondary mutations within the same c-KIT or PDGFRA...

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